Diazepam (Valium) was developed by the Swiss pharmaceutical
giant Hoffmann-La Roche in early 1960's and approved for use in 1963. Its
predecessor, chlordiazepoxide, was two and a half times less effective and
diazepam has quickly surpassed it in sales. When Valium saw a huge success on
the market other pharmaceutical companies have started to introduce their own
benzodiazepine derivatives to compete with the new drug.
The benzodiazepines have quickly become a suitable
substitute for barbiturates among healthcare professionals because of their
wide potency and almost harmless effects. In therapeutic doses diazepam has
much stronger sedative effect as compared to barbiturates. It is also much
safer to use with very rare cases of lethal overdose, which has usually
resulted from mixing Diazepam with other
depressing substances such as alcohol or sedatives.
Since 1969 Valium
was the most sold drug in the United States with a peak in 1978 when 2.3
billion tablets were sold. For the last forty years Valium remains to be one of
the most prescribed drugs all over the world. It has also entered the list of
core medications by the World Health Organisation, which means it is mandatory
for any basic healthcare system. During its history, diazepam has shifted its
primary use between different areas of pharmacology. First it was used mainly
by psychiatrists for the short-term treatment of anxiety. Today Valium is
mainly used by neurologists who pr
escribe it for treating certain types of
epilepsy and spastic activity. Valium is also one of the main drugs that is
used for treating a rare condition called stiff-person syndrome.
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